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References to Research & Scientific Studies on RLT and Skin

1. Light therapy as a treatment for photoaging skin

TitleLight therapy as a treatment for photoaging skin
Conducted byDavid J Goldberg, Snehal Amin, Bruce A Russell, Robert Phelps, Norma Kellett, Laurence A Reilly1
Published onSeptember 5th, 2006
JournalJournal of drugs in dermatology
Number of participantsThirty-six subjects

Method of study:

Thirty-six volunteers were required to undergo Light therapy treatment for a period of 5 weeks. The light therapy was administered by 9 LED and after 12 weeks the results were tabulated. The wavelength of the lights was 633 nm(Red) and 830nm (Infrared).


The study found there was a statistical difference in the amount of wrinkled after the administration of light therapy treatment. Out of the 36 subjects, the majority also experienced an improvement in the softness, smoothness, and firmness of the skin. Furthermore, an Electron microscopic analysis showcased thicker collagen fibers. The study concluded that 633-nm and 830-nm LED treatments to play a significant role in the treatment of photodamaged skin

2. A study on the effects of light therapy on facial skin

Title Photodynamic photorejuvenation of the face with a combination of microneedling, red light, and broadband pulsed light
Conducted byMatteo Tretti Clementoni MD, Marc B-Roscher MD, Girish S. Munavalli MD, MHS
Published on 17 February 2010
JournalLasers in Surgery and Medicine
Number of participants21

Method of study: 

A full-face treatment of 21 volunteers was performed by only using 30 nm light and broadband pulsed light. The results of the treatment were then assessed by three separate physicians.


The study yielded extremely positive results. Each of the 21 participants of the study showed an increase in global photoaging scores, in another word it was statistically proven that each of the 21 participants experienced a decrease in wrinkles. The study also showed that light therapy could be used as an anti-aging treatment.

3. A study on the effects of light therapy on skin rejuvenation

TitleA prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings
Conducted bySeung Yoon Lee, Ki-Ho Park, Jung-Woo Choi, Jung-Kyun Kwon, Doo Rak Lee, Mi Sun-Shin, Jee Sung Lee, Chung Eui You, Mi Youn Park
Published onMay 1st, 2007
JournalJournal of photochemistry and photobiology
Number of participants76

Method of study:

The study was limited to seventy-six patients. Each of the 76 patients exhibited some form of facial wrinkles. The 76 patients were divided into 4 groups and were treated with quasimonochromatic LED devices. Each of the 4 groups was treated with LED lights; the first group received 830nm of light, the second group received 633nm of light, the third received a combination of 830 and 633nm, while the last group was the placebo group.


The study’s findings were mostly consistent with other studies of the past. The study found that light therapy leads to a significant reduction in wrinkles and greatly increases the elasticity of the skin as compared to the placebo group. The study concluded that 830 and 633nm wavelengths of light can serve as an effective treatment for skin rejuvenation

4. A study on light therapy as a means to cure acne

Title Topical aminolevulinic acid-photodynamic therapy for the treatment of acne vulgaris 
Conducted bySeok-Beom Hong, Mu-Hyoung Lee
Published on 21st December 2005
Journal Photodermatology, Photoimmunology, and Photomedicine
Number of participants8 patients

Method of study:

For the purpose of this study, eight individuals exhibited mild to moderate acne vulgaris on the face. To combat the acne the patients were treated with one session of topical aminolevulinic acid (ALA)-PDT using a red light. The treated patients were monitored for 6 months.

Key Findings:

The trial yielded an extremely positive result and found a very clear correlation between light therapy and acne. ALA-PDT with red light was found to be very effective in the reduction of facial acne. The study further found that the treatment had no adverse reactions.

5.  A study on light therapy and its effect on skin graft

Title Effects of red and near-infrared LED light therapy on full-thickness skin graft in rats
Conducted byCintia Cristina Santi Martignag , Carla Roberta Tim, Lívia Assis , Viviane Ribeiro Da Silva, Estefany Camila Bonfim Dos Santos , Fabiana Nascimento Vieira, Nivaldo Antonio Parizotto, Richard Eloin Liebano
Published onFebruary 2020
Journal Lasers in Surgery and Medicine
Number of participants30 rats

Method of study:

A total of 30 rats were chosen for this experiment. the 30 rats were randomly divided into 3 groups. The first group was the control group, the second group was the red light therapy group and the third group was the near-infrared light therapy group. Skin grafts were irradiated daily for ten consecutive days.

Key findings: 

The study found that red light therapy effectively improves the dermo-epidermal junction and modulates the expression proteins. This means that red light therapy can not only reduce the amount of scar tissue but can also be extremely beneficial for skin graft patients.

6. Light therapy as an anti-acne measure

TitleThe Anti-Acne Effect of Near-Infrared Low-Level Laser Therapy
Conducted byAnna Szymańska , Elzbieta Budzisz , Anna Erkiert-Polguj 
Published on25th August 2021
JournalClinical, cosmetic and investigational dermatology
Number of participantsNone

Method of study:

This review paper strives to uncover the many mysteries behind the light therapy process. Its basic aim is to explain the complicated process of energizing the cell by virtue of light therapy to the everyday layman. The paper also highlights the effectiveness of the light therapy process by pointing to other researches done in the past that show a common result: light therapy is effective.

Key findings:

For the most part, the paper only concerns itself with light therapy and its treatment of acne. The paper highlights how light therapy can be an effective form of treatment against acne. It also points at other studies done in the past that have concluded that light therapy is effective from skincare treatment. The paper also goes to great length to stress the safety aspect of light therapy.

7. Light therapy and facial acne.

TitleImprovement of facial acne scars by the 585 nm flashlamp-pumped pulsed dye laser 
Conducted byT S Alster, T O McMeekin
Published on July 1996
Journal Journal of the American Academy of Dermatology
Number of participants22

Method of study:

The study strives to find out the result of the 585nm wavelength of light on facial acne scars. For the purpose of the study, a total of 22 patients were selected and treated with of 585nm wavelength that was emitted by an experimental flashlamp-pumped pulsed dye laser. A control group was also kept as a safety precaution to measure the progress of the treated group

Key findings:

The study as a whole yielded largely positive results. There was a significant reduction in facial acne scars of the treatment group as compared to the control groups. The 585nm wavelength of light was effective in reducing the number of facial acne scars. The researches further stresses the need for further research on the subject.

8. A study on light therapy and its effects on skin

TitleA Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase
Conducted byAlexander Wunsch and Karsten Matuschka
Published onFeb 2014
JournalJournal Photomedicine and Laser Surgery
Number of participants 136

Method of study:

136 people volunteered and were put randomly into 4 groups. The 4 groups were treated by using light therapy twice a week by using either 611–650 or 570–850 nm polychromatic light.


The study’s main purpose was to explore the effects of light therapy on some basic skin issues. The researchers as a result of this study found light therapy could:

  • Lead to a rejuvenation of the skin
  • Improve the complexion of the skin
  • Improve the look and feel of the skin

The study also found that the group exposed to light had an increase in collagen density and lower mean skin roughness, compared to the controlled group, who were not exposed to light therapy.

9. A study on light therapy and its effect on the skin

TitleLow-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring
Conducted byPinar Avci, MD, Asheesh Gupta, Ph.D., Magesh Sadasivam, MTech,1Daniela Vecchio, Ph.D., Zeev Pam, MD, Nadav Pam, MD, and Michael R Hamblin, PhD
Published onMarch 2013
JournalSeminars in Cutaneous Medicine and Surgery
Number of participantsNone

Method of study:

The study studied the effect of light therapy on the mitochondria of the cell. The study also refers to several previous studies on the subject to hypothesize about the potential benefits of light therapy on skincare.


The study showered the mitochondria with light particles. These light particles were absorbed by the cells and turned into energy, leading to an increase in the production of adenosine and triphosphate. The study postulated that this increased energy was why Red light therapy could cure acne and help with skincare.


  1. Combined 633-nm and 830-nm led treatment of photoaging skin
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