References to Research & Scientific Studies on RLT and Skin

1. Red Light Therapy (RLT) to treat photodamaged ageing skin

TitleCombined 633-nm and 830-nm led treatment of photoaging
Conducted byDavid J Goldberg, Snehal Amin, Bruce A Russell, Robert Phelps, Norma Kellett, Laurence A Reilly
Published onSeptember 5th, 2006
JournalJournal of drugs in dermatology
Number of participants36

Method of study:

Thirty-six volunteers received 9 Red Light therapy treatments at the wavelength of 633 nm(Red) and 830nm (Infrared) for a period of 5 weeks and the final assessment was done after 12 weeks.


The study found a statistical difference in the number of wrinkles after the administration of light therapy treatment (LLLT). Out of the 36 subjects, the majority experienced an improvement in the softness, smoothness, and firmness of the skin. An Electron microscopic analysis showcased thicker collagen fibres. The study concluded that 633-nm and 830-nm LED treatments play a significant role in the treatment of photodamaged skin.

2. A study on the effects of light therapy on facial skin

TitlePhotodynamic photorejuvenation of the face with a combination of microneedling, red light, and broadband pulsed light
Conducted byMatteo Tretti Clementoni MD, Marc B-Roscher MD, Girish S. Munavalli MD, MHS
Published on 17 February 2010
JournalLasers in Surgery and Medicine
Number of participants21

Method of study: 

A group of 21 patients underwent a full-face treatment which involved using 630 nm light and broadband pulsed light after multiple passes with a microneedle roller and 1-hour ALA incubation. The primary endpoint was to assess clinical improvement by three blinded physicians. The secondary endpoint was to evaluate patient satisfaction based on comparing baseline to 6-month post-treatment.

Key Findings:

Statistically significant improvement was seen in global photoaging scores and sub-components of the scale90% of patients judged clinical improvement to be greater than 50% at 6 months compared to baseline photography. The use of microneedle roller pre-treatment prior to ALA application allows for even absorption and deeper penetration of ALAThe use of red light and broadband pulsed light allowed for deeper activation of ALA and marked clinical improvement in photoaging.

3. A study on the effects of light therapy on skin rejuvenation

TitleA prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings
Conducted bySeung Yoon Lee, Ki-Ho Park, Jung-Woo Choi, Jung-Kyun Kwon, Doo Rak Lee, Mi Sun-Shin, Jee Sung Lee, Chung Eui You, Mi Youn Park
Published onMay 1st, 2007
JournalJournal of photochemistry and photobiology
Number of participants76

Method of study:

The study was limited to seventy-six patients. Each of the 76 patients exhibited some form of facial wrinkles. The 76 patients were divided into 4 groups and were treated with quasimonochromatic LED devices. Each of the 4 groups was treated with LED lights; the first group received 830nm of light, the second group received 633nm of light, the third received a combination of 830 and 633nm, while the last group was the placebo group.

Key Findings:

The study’s findings were mostly consistent with other studies of the past. The study found that light therapy leads to a significant reduction in wrinkles and greatly increases the elasticity of the skin as compared to the placebo group. The study concluded that 830 and 633nm wavelengths of light can serve as an effective treatment for skin rejuvenation

4. A study on light therapy for the treatment of acne vulgaris

TitleTopical aminolevulinic acid-photodynamic therapy for the treatment of acne vulgaris 
Conducted bySeok-Beom Hong, Mu-Hyoung Lee
Published on 21st December 2005
Journal Photodermatology, Photoimmunology, and Photomedicine
Number of participants8 patients

Method of study:

The study involved treating 8 patients who had mild-to-moderate acne on their faces. A topical aminolevulinic acid (ALA)-PDT treatment was applied with red light. Each patient's face was divided into two areas – one treated with the PDT treatment and the other untreated. The treatment involved applying 20% ALA and administering 18 J/cm of red light. The patients' acne was visually assessed at baseline and 1, 3, and 6 months following the treatment.

Key Findings:

The trial yielded an extremely positive result and found a very clear correlation between light therapy and acne reduction. ALA-PDT with red light was found to be very effective in the reduction of facial acne.

The study further found that the treatment had no adverse reactions.

5.  A study on light therapy and its effect on skin grafts

Title Effects of red and near-infrared LED light therapy on full-thickness skin graft in rats
Conducted byCintia Cristina Santi Martignag , Carla Roberta Tim, Lívia Assis , Viviane Ribeiro Da Silva, Estefany Camila Bonfim Dos Santos , Fabiana Nascimento Vieira, Nivaldo Antonio Parizotto, Richard Eloin Liebano
Published onFebruary 2020
Journal Lasers in Surgery and Medicine
Number of participants30 rats

Method of study:

The study aimed to see how different types of light-emitting diodes (LEDs) affect skin grafts in rats. Thirty rats were divided into three groups – a control group, a group treated with red LED(630 nm), and a group treated with near-infrared LED(850 nm). The skin grafts were exposed to the LED light for 10 days after the surgery. The study aimed to see how the different LED types impacted the skin grafts.

Key findings: 

The red wavelength LED had a significant impact on the skin graft score, compared to the NIR group. The red wavelength LED increased the density of collagen fibres, compared to the other experimental groups. These results suggest that the red wavelength LED is beneficial to reduce scar tissue, promoting collagen production and faster healing of the skin.

6. Light therapy as an anti-acne measure

TitleThe Anti-Acne Effect of Near-Infrared Low-Level Laser Therapy
Conducted byAnna Szymańska , Elzbieta Budzisz , Anna Erkiert-Polguj 
Published on25th August 2021
JournalClinical, cosmetic and investigational dermatology
Number of participants27

Method of study:

The study involved 27 women between the ages of 18 and 45 who had mild to severe acne. They received six treatments every two weeks using a 785 nm low-level laser. The effectiveness of the treatments was measured by examining sebum, taking pictures, and assessing the change in the number of acne lesions.

Key findings:

Significant improvements in acne lesions and a significant decrease in skin sebum excretion were observed after the treatment. No adverse effects were reported.A series of six treatments using a near-infrared low-level laser represents a safe and effective non-invasive therapy option for acne vulgaris.

7. A study on light therapy and its effects on skin

TitleA controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase
Conducted byAlexander Wunsch and Karsten Matuschka
Published onFeb 2014
JournalJournal Photomedicine and Laser Surgery
Number of participants 136

Method of study:

136 people volunteered and were put randomly into 4 groups. The 4 groups were treated by using light therapy twice a week by using either 611–650 or 570–850 nm polychromatic light.

Key Findings:

The study’s main purpose was to explore the effects of Red and Near-Infrared Light Treatment on the Reduction of Fine Lines, Wrinkles, Skin Roughness, and on Intradermal Collagen Density.The researchers found that light therapy could lead to a rejuvenation of the skin, improve the complexion of the skin, and improve the look and feel of the skin.The study also found that the group exposed to light had an increase in collagen density and lower mean skin roughness compared to the control group, who were not exposed to light therapy.

8. A study on light therapy and its effect on the skin

TitleLow-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring
Conducted byPinar Avci, MD, Asheesh Gupta, Ph.D., Magesh Sadasivam, MTech,1Daniela Vecchio, Ph.D., Zeev Pam, MD, Nadav Pam, MD, and Michael R Hamblin, PhD
Published onMarch 2013
JournalSeminars in Cutaneous Medicine and Surgery
Number of participantsNone

Method of study:

The study studied the effect of light therapy on the mitochondria of the cell. The study also refers to several previous studies on the subject to hypothesize about the potential benefits of light therapy on skincare.

Key Findings:

Low-level laser therapy (LLLT) has a wide range of applications in dermatology, particularly for stimulating healing, reducing inflammation, reducing cell death, and skin rejuvenation.LLT can be used for both repigmentation of vitiligo and the depigmentation of hyperpigmented lesions LED array-based devices have made LLLT application simpler for larger areas of skin.