1. Red Light Therapy ( LLLT) for neuropathic pain relief
| Title | Effects of 660- and 980-nm low-level laser therapy on neuropathic pain relief following chronic constriction injury in rat sciatic nerve |
| Conducted by | M. Masoumipoor, S. B. Jamie, A. Janzadeh, F. Nasirinezhad, M. Soleimani & M. Kerdary |
| Published on | 16th March 2014. |
| Journal | Lasers in Medical Science (LIMS) |
| Number of participants | 30 Wistar adult male rats |
Method of study:
The study examined the effects of different wavelengths of low-level laser therapy (LLLT) on the injured sciatic nerve in a Chronic constriction injury (CCI) model for neuropathic pain.30 male rats were used and randomly divided into three groups.CCI was used to induce neuropathic pain in the sciatic nerve. Both wavelengths of LLLT (660 nm and 980 nm) were applied for two weeks. Mechanical and thermal hyperalgesia was evaluated before and after surgery.
Findings:
The study concluded that Low-level laser therapy may be used for clinical application in neuropathic cases and the most effective wavelength is 660-nm.
2. Low-level laser therapy for cervical disk hernia, neck and back pain
| Title | Low level laser therapy for patients with cervical disk hernia, neck and back pain |
| Conducted by | Hiroshi Takahashi, Ikuko Okuni, Nobuyuki Ushigome, Takashi Harada , Hiroshi Tsuruoka, Toshio Ohshiro, Masayuki Sekiguchi, Yoshiro Musya |
| Published on | September 2012 |
| Journal | Journal for laser surgery, phototherapy and photoactivation |
| Number of participants | 26 |
Method of study:
The study involved 26 rehabilitation department outpatients with chronic neck pain caused by cervical disk hernia. The patients underwent treatment using a 1000 mW semi-conductor laser device delivering at 830 nm in continuous wave. The device delivered 20.1 J/cm(2)/point, and three shots were given per session (1 treatment).
Treatment was administered twice a week for 4 weeks.
Key findings:
The study shows that LLLT is an effective form of treatment for neck and back pain caused by cervical disk hernia, reinforced by postural training.
3. A study of Red Light Therapy and its anti-inflammatory wound healing properties.
| Title | Photobiomodulation with 808-nm diode laser light (NIR) promotes wound healing of human endothelial cells |
| Conducted by | Andrea Amaroli , Silvia Ravera , Francesca Baldini , Stefano Benedicenti, Isabella Panfoli , Laura Vergani |
| Published on | 3rd April 2019 |
| Journal | Lasers in Medical Science (LIMS) |
| Number of participants | Only human endothelial cells were used |
Method of study:
The study assessed the effects of near-infrared light (NIR) 808-nm light on inflammation-induced human endothelial cells (HECV). The cells were irradiated and then compared to the control group.
Key findings:
The study found that near-infrared light at 808-nm wavelength (NIR) led to a shift from anaerobic to aerobic metabolism of the cells and this explains the mechanisms by which photobiomodulation protects against inflammation-induced endothelial dysfunction. NIR/LLLT is therefore of therapeutic use for its anti-inflammatory and wound-healing benefits.
4. Red Light Therapy (LLLT) to treat chronic knee joint pain
| Title | Low Level Laser Therapy for chronic knee joint pain patients |
| Conducted by | Takashi Nakamura , Satoru Ebihara , Ikuko Ohkuni , Hideaki Izukura , Takashi Harada , Nobuyuki Ushigome, Toshio Ohshiro , Yoshiro Musha , Hiroshi Takahashi , Kazuaki Tsuchiya , Ayako Kubota |
| Published on | December 2014 |
| Journal | Journal for laser surgery, phototherapy and photoactivation |
| Number of participants | 35 |
Method of study:
The study involved 35 subjects with chronic knee joint pain caused by knee osteoarthritis-induced degenerative meniscal tear. The subjects received low level laser therapy using a 1000 mW semi-conductor laser device. The device delivered 20.1 J/cm(2) per point in continuous wave at 830nm. Four points were irradiated per session (1 treatment) twice a week for 4 weeks.
Findings:
Significant improvement was observed in all participants after the completion of the treatment course. The study demonstrated that the use of 830 nm low-level laser therapy (LLLT) is effective in treating chronic joint pain caused by knee osteoarthritis and would therefore be of therapeutic use also in other similar joint pain conditions.
5. LLLT to control neuropathic pain
| Title | Use of low level laser therapy to control neuropathic pain A systematic review |
| Conducted by | Ana Laura Martins de Andrade, Paulo Ségio Bossini, Nivaldo Antônio Parizotto |
| Published on | November 2016 |
| Journal | Journal of photochemistry and photobiology |
| Number of participants | 26 |
Method of study:
The study conducted an analysis of existing literature on the application of low-level laser therapy (LLLT) for the management of neuropathic pain. The purpose of this review was to determine the optimal LLLT treatment parameters. The review included 14 articles, with 10 studies involving animal models and 4 studies conducted on human subjects.
Key findings:
Clinical studies are inconclusive as to the best treatment parameters to apply however the data analyzed indicates that LLLT is of benefit to control neuropathic pain.
6. Low Level Laser Therapy for Radial Nerve Palsy Patients
| Title | Low Level Laser Therapy for Radial Nerve Palsy Patients |
| Conducted by | Chikara Oshima, Hitoshi Nakazawa, Hideaki Izukura, Midori Miyagi, Akito Mizutani, Takashi Harada, Toshio Ohshiro, Satoru Ebihara |
| Published on | March 2018 |
| Journal | Journal for laser surgery, phototherapy and photoactivation |
| Number of Participants | 13 |
Method of study:
13 patients with radial nerve palsy were treated with LLLT. Treatment consisted of LLLT 830 nm was administered, with five points treated per session, twice a week for 3 months. 6 patients received brace therapy in conjunction with LLLT
Key findings:
Excellent improvement was observed in 9 out of 13 cases with LLLT treatment. Combination treatment (laser therapy with bracing) showed 4 excellent cases out of 6. It is concluded that LLLT is an effective treatment for radial nerve palsy.
7. Low-Level Laser Therapy (LLLT) for Diabetic Neuropathy
| Title | Low-Level Laser Therapy (LLLT) and Gabapentin in the Management of Peripheral Neuropathy: Diabetic Neuropathy |
| Conducted by | Khaled G Abdel-Wahhab, Eitedal M Daoud, Aliaa El Gendy, Hagar H Mourad, Fathia A Mannaa, Maha M Saber |
| Published on | September 2018 |
| Journal | Journal of solid-phase biochemistry |
| Number of Participants | Not Stated |
Method of study:
The study was conducted on diabetic rats with peripheral diabetic neuropathy (DNP). Behavioural tests (hotplate and Morris water maze) and biochemical analysis were performed. LLLT and gabapentin were compared as treatments for DNP.
Key findings:
LLLT improved pain and memory better than gabapentin. LLLT decreased S100B and markers of oxidative stress and inflammation. LLLT was more effective and safer than gabapentin in managing neuropathy.
8. Low Level Laser Therapy in patients with chronic foot and ankle joint pain
| Title | Low Level Laser Therapy in patients with chronic foot and ankle joint pain |
| Conducted by | Hideaki Izukura, Midori Miyagi, Takashi Harada , Toshio Ohshiro, Satoru Ebihara |
| Published on | March 2017 |
| Journal | Journal for laser surgery, phototherapy and photoactivation |
| Number of Participants | 17 |
Method of study:
17 patients visited the outpatient clinic for chronic foot and ankle joint pain, the pain had various causes. Patients received LLLT (low-level laser therapy) using at 830 nm in continuous wave. Patients received four shots per session per foot and treatment was administered twice a week for 4 weeks.
Key findings:
Significant improvement was observed after the treatment regimen. All patients except 2 showed improvement: excellent (2) and good (13). Postural education, in combination with LLLT, was found to be an effective treatment for chronic foot and ankle joint pain.
