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References to Research & Scientific Studies on RLT and Pain Relief

1. A study on light therapy as a pain relief measure

TitleEffects of 660- and 980-nm low-level laser therapy on neuropathic pain relief following chronic constriction injury in rat sciatic nerve
Conducted byM. Masoumipoor, S. B. Jamie, A. Janzadeh, F. Nasirinezhad, M. Soleimani & M. Kerdary 
Published on16th March 2014.
Journal Lasers in Medical Science (LIMS)
Number of participantsThirty Wistar adult male rats (230–320 g) were used for the study

Method of study:

The study primarily focuses on light therapy as a pain relief for Neuropathic pain. The study used different wavelengths of LLLT in the injured sciatic nerve, to study the effects of LLLT on neuropathic pain. For the purposes of this study, the researchers used thirty Wistar adult male rats. The rats were divided into 3 groups.


The study concluded that Low-level laser therapy can ably treat Neuropathic pain. The study further highlights that 660-nm wavelengths had better therapeutic effects than the 980-nm wavelength. The 660nm showcases the great potential for use in clinical application and should be the focus of further studies.

2. A study of light therapy and its anti-inflammatory properties.

TitlePhotobiomodulation with 808-nm diode laser light promotes wound healing of human endothelial cells through increased reactive oxygen species production stimulating mitochondrial oxidative phosphorylation 
Conducted byAndrea Amaroli , Silvia Ravera , Francesca Baldini , Stefano Benedicenti, Isabella Panfoli , Laura Vergani
Published on3rd April 2019
JournalLasers in Medical Science (LIMS)
Number of participantsOnly human endothelial cells were used

Method of study:

Only human endothelial cells were used for the purpose of this trial. The cells were showered with 808 wavelengths of light. The cells that were exposed to the light were then compared to a control group of cells.

Key findings:

The results of the study clearly pointed to the positive correlation between the 808 wavelengths of light and the metabolism of the human endothelial cell. 808 nm of light meant a higher metabolism, higher metabolism meant better pain relief and wound rejuvenation.

3. A study on light therapy to treat pain stemming from rheumatoid arthritis 

TitleLow-level laser therapy (classes I, II, and III) in the treatment of rheumatoid arthritis 
Conducted byL Brosseau, V Welch, G Wells, R deBie, A Gam, K Harman, M Morin, B Shea, P Tugwell
Published on October 2005
JournalCochrane Database of Systematic Reviews
Number of participants204 patients

Method of study: 

The study consisted of 204 patients. The 204 patients were divided into two groups. Each group consisted of 112 patients. The first group was exposed to light therapy while the second group of 112 patients served as the control group.


The study concluded that light therapy can effectively treat pain from rheumatoid arthritis. The study further points out that light therapy is most effective when applied for a period of 4 weeks.

4. A study on Low-level laser therapy as a treatment for chronic joint pain.

TitleA systematic review of low-level laser therapy with location-specific doses for pain from chronic joint disorders
Conducted byJan M Bjordal , Christian Couppé, Roberta T Chow, Jan Tunér, Elisabeth Anne Ljunggren
Published on3rd Jan 2003
JournalThe Journal of Physiotherapy 
Number of participantsA review of 88 random trials on the subject

Method of study: 

The review randomly chooses 88 trials to determine the efficacy of light therapy as a treatment for chronic joint pain. The reviewers painstakingly reviewed each study to determine the legitimacy of each review.


The review declared the results of 80 trials to be legitimate and furthermore concluded that doses of light therapy can greatly alter the amount of pain experienced by a person.

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